Absolutely! You interact with them the same way you would any element... By xpath, id, classname, etc.
But this question was mainly about extracting data from large table view pages. Meaning, reading the information on the page, and not really interacting with the items on the page. Interacting with 100s of items on a page, such as entering text, or clicking on them, is unfortunately going to be slow, and grabbing page source won't likely help much there. unless your interaction is just do they exist or not.